CDL-Toronto Advanced Therapies

CDL-Toronto Advanced Therapies is a mentorship-driven program that accelerates early-stage ventures developing groundbreaking therapeutics by connecting them with world-class scientists, investors, and entrepreneurs.
  • CDL-Toronto
Overview of the CDL-Toronto Advanced Therapies program:

The CDL Advanced Therapies Stream, hosted at the Rotman School of Management, University of Toronto, is part of Creative Destruction Lab’s Health domain and focuses on early-stage biotech ventures working on next-generation therapeutics. This highly selective program helps ventures working on modalities such as gene therapy, cell therapy, mRNA platforms, engineered proteins, and biologics bring their innovations closer to clinical or commercial success. Over a 9-month period, selected companies engage with CDL’s global network of mentors including experienced biotech founders, operators, pharmaceutical executives, angel investors, and venture capitalists. They receive strategic guidance tailored to their technical, regulatory, and business challenges. Companies are expected to identify key objectives at each program session and work toward eliminating critical risks before the next. This milestone-driven process ensures only the highest-potential companies remain in the program. CDL’s non-dilutive model—no fees and no equity taken—offers immense value, particularly for science-heavy startups navigating long and expensive development timelines. In addition to business mentorship, CDL’s Advanced Therapies stream provides access to scientific advisors from leading academic institutions and R&D-intensive companies. Ventures benefit from feedback on preclinical and clinical strategies, IP positioning, regulatory roadmaps, and partnership development. The program also enhances investor readiness by connecting companies to life sciences-focused VCs and pharma partners aligned with their stage and scientific domain.

Benefits of the CDL-Toronto Advanced Therapies program:
  • Structured 9-month accelerator tailored to advanced therapy companies
  • Mentorship from pharma leaders, scientists, biotech entrepreneurs, and investors
  • Direct support on clinical trial planning, regulatory strategy, and business models
  • Input from CDL Fellows, who are accomplished operators and investors in the biotech field
  • Objective-based sessions ensure milestone tracking and tangible progress
  • Participation leads to investor-readiness and industry exposure
  • Guidance in navigating complex biotech lifecycles (e.g., IP, FDA/Health Canada, partnerships)
  • Zero cost to participants CDL takes no equity and charges no fees
Eligibility criteria of the CDL-Toronto Advanced Therapies program:
  • To be eligible for CDL-Toronto Advanced Therapies, companies must:
  • Stage: Be early-stage biotech ventures (preclinical, IND-enabling, or early clinical)
  • Technology Focus:
  • Gene and cell therapies
  • RNA-based platforms (e.g., mRNA, siRNA)
  • Biologics (e.g., monoclonal antibodies, engineered proteins)
  • Novel delivery platforms
  • Science-Driven: Must have strong scientific underpinnings with potential for high therapeutic impact
  • Team: Include at least one technical/scientific founder and one business or operations lead
  • Location: Open to global companiesnot restricted to Canadian ventures
  • Scalability: Should demonstrate potential for transformative clinical or commercial value
  • Commitment: Must attend five full-day sessions over nine months (virtual or hybrid format)
  • Regulatory Path: Must show understanding ofor willingness to learnregulatory and IP pathways
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